Benzathine benzylpenicillin: incazelo, properties kanye isicelo, analogs

Benzathine Benzylpenicillin kuyinto-antibiotic futhi kungokwalabo iqembu i-penicillin. Asetshenziselwa ukwelapha zonke izinhlobo zezifo ezithathelwanayo ezibangelwa amagciwane ukungenwa wesenzo. Kulesi sihloko sizobona ukuthi kubekwe ngokuningiliziwe yokusetshenziswa, izinkomba kanye contraindications emuthini, kanye uhlu a ontanga ambalwa.

Benzathine benzylpenicillin: incazelo izidakamizwa

Lesi sidakamizwa ingenye iqembu lokuqala penicillin elwa namagciwane. Naphezu isicelo eside kakhulu elithi, ke akalilahlile ngokuhlathulula ukusebenza kwawo ngenxa ezahlukene izenzo kanye nekhono ukubulala ezihlukahlukene namagciwane abangela izifo. Umuthi, isibonelo, ungakwazi yini ukuyikhulisa kahle i-anthrax, meningococci, ugcunsula kanye sebuningini streptococci futhi staphylococci. Ingabe injected njengasezulwini ipheshana yesisu is hhayi matasa benzathine benzylpenicillin.

Recipe ngesiLatini ngokuvamile ebekwe odokotela, bese isiguli kunzima ukuqonda ukuthi yini wanikwa. Ukuze ugweme lokhu kudideka, udinga nje ukwazi igama izidakamizwa ngalolu limi - Benzathine benzylpenicillinum.

Ngokuvamile, izidakamizwa iqondiswa ngemithambo yegazi noma intramuscularly. Kodwa kungenzeka futhi izidakamizwa ukulethwa emzimbeni ngokusebenzisa umgogodla emseleni, phansi kwesikhumba noma ngokusebenzisa endaweni ethintekile.

Benzylpenicillin --antibiotic siqanjwe kusuka ketshezi asebenzayo efanayo. Kodwa-ke engena izidakamizwa ngesimo nosawoti. Ngakho ketshezi zingagcinwa isikhathi eside ngaphandle ukuphuka. Futhi emva kusungulwa i-penicillin G ukhululeka emzimbeni nosawoti bese iqala wesenzo elwa namagciwane.

Kuye ngokulandelana Usawoti nemiyo esebenzayo, kukhona izinhlobo eziningana imithi. Naphezu kwakho konke lokhu, konke cishe umphumela ofanayo, futhi izindlela ezahlukene abaphathi kanti isikhathi nomphumela.

ubufakazi

Benzathine benzylpenicillin ezinqunyiwe lezi zifo ezilandelayo:

• Ezithathelana kwezitho zokuphefumula (pleurisy, inyumoniya, ukucinana kwemigudu yokuphefumula, empyema , kanjalonjalo.).
• Izifo kohlelo genitourinary (ugcunsula, isipatsholo, urethritis, cystitis, adnexitis, salpingitis).
• Izifo of engenhla ipheshana zokuphefumula (scarlet fever, namathansela, sinusitis, abezindaba otitis, sinusitis, laryngitis, njll).
• Ubovu izifo kwezitho ezibukwayo, amathambo kanye isikhumba, nolwelwesi lwamafinyila (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, Erysipelas, cellulitis, ukutheleleka ukulimaza, nokunye.).
• Brain ithumba.
• Ubovu meningitis.
• Septicemia, sepsis.
• Isifo sokuqaqamba kwamalunga.
• Peritonitis.
• Izifo ezibangwa spirochetes (yaws, umbendeni, njll).
• Fever kubangelwa rat bite.
• Ezithathelana kubangelwa Listeria, Clostridium, Pasteurella.

Ngaphezu kwalokho, lo izidakamizwa iqondiswa e yezinkinga prophylactically nasezinkingeni ezilandela ngemva kokuhlinzwa kanye ukutheleleka streptococcal (endocarditis, imfiva ye-rheumatism, glomerulonephritis nokunye.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) ngokushesha ngemva kokuphathwa iqala iba yingxenye yomhlabathi, idedela izidakamizwa esebenzayo. Ngesikhathi esifanayo izidakamizwa uhlala egazini emva amaviki 3 umjovo. Ingqikithi ketshezi lingena ingcono kakhulu e nezicubu. Kumele kukhunjulwe ukuthi Gcoba i-Benzyl penicillin akuzange kusize uyakwazi yokunqoba isithiyo esibangwa esinomhlapho futhi avele ubisi nabancelisayo. Excreted ngokusebenzisa izinso ngefomu zinjalo. Ezinsukwini zokuqala 8 ezikhishwe mayelana 33% umthamo iqondiswa.

Ukukhulelwa ibele

Njengoba kuphawulwe ngenhla, umuthi ezikwazi ukuhlaba zingene placenta sibhujiswa futhi singene ubisi lwebele. Ngakho-ke, ibele kufanele kwayekwa lapho ukuphatha izidakamizwa.

Phakathi nenkathi yokukhulelwa, ukuqokwa izidakamizwa kungenzeka kuphela uma inzuzo kwabesifazane mkhulu izingozi ingane. Isinqumo kufanele kwenziwe udokotela, isixwayiso umama esizayo mayelana yonke imiphumela kunokwenzeka.

Izimo

Benzathine benzylpenicillin (iresiphi angabeka udokotela) enezinto eziningi Izimo. Akumele elibekelwe abantu izifo elandelayo:

• Ubandlululo-penicillin noma cephalosporin, ukusabela iguliswa kubo.
• Izinga eliphezulu potassium egazini (hyperkalaemia).
• Arrhythmia.
• Hay fever.
• isifuba somoya bronchial.
• esingamahlalakhona kwezinso.
• nesifo Pseudomembranous.

Okumele kuqashelwe nomuthi zaphathwa izingane izinyanga eziyisithupha futhi ngaphambi kwesikhathi.

side effects

Benzathine benzylpenicillin kungadala ezinye imiphumela engathandeki, zibhale ngezansi.

ukusabela abahlukahlukene iguliswa:

• umkhuhlane;
• isifuba;
• awahlabi ku nolwelwesi lwamafinyila kanye isikhumba;
• ubuhlungu bamalunga;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• dermatitis exfoliative;
• ukushaqeka anaphylactic.

ukusabela ezingezinhle kohlelo senhliziyo:

• thrombocytopenia;
• anaemia;
• coagulation iziyaluyalu;
• leukopenia.

Ngaphezu kwalokho:

• stomatitis;
• ukuphathwa ikhanda;
• glossitis;
• ubuhlungu endaweni yokuphathwa;
• abscesses;
• lingene;
• jade neuropathy;
• fistulas.

Ngekusetjentiswa isikhathi eside isikhunta eziyingozi kanye amagciwane ingaqala ukumelana ke izidakamizwa uzolahlekelwa ekulenzeni libe namandla.

Benzathine benzylpenicillin: yokusetshenziswa

Iziguli abaneminyaka engama 12, izidakamizwa njengoba isilinganiso zokuvimbela futhi ukwelapha izifo ezithathelwanayo iqondiswa kanye ngesonto ngesikhathi umthamo 300 kuya kwezingu-600. Amayunithi noma kabili ngenyanga at amayunithi angu-1.2 million.

Njengoba izinyathelo zokuvimbela ngoba rheumatism kwabathinta ikhambi amasonto 6, kanye ngesonto ukuze amayunithi ayizinkulungwane 600. Ngesikhathi esifanayo linqume aspirin noma ezinye ama-NSAID.

Iziguli ezingaphansi kuka engu-12, umuthi iqondiswa kanye ngesonto ngesilinganiso ayizinkulungwane 5-10. Amayunithi ngalinye 1 kg.

Phakathi imijovo okufanele kwenzeke ezinsukwini ezingu-8. Umthamo isilinganiso amayunithi kwezigidi ezingu-2.3.

Ngaphambi ukusetshenziswa, umuthi ziyoncibilika nosawoti, amanzi umjovo okukhethekile noma novocaine (2.5% noma 5%).

Ibe isidakamizwa kungenzeka ngezindlela ezilandelayo:

• esicutshini;
• emthanjeni;
• ongama;
• Lumbar (nge umsele umgogodla);
• pleural (ngokusebenzisa pleura yamaphaphu);
• subconjunctival (nge kwezicubu ocular);
• iconsa ngokusebenzisa indlebe;
• iconsa ngokusebenzisa ikhala;
• ngqo abathintekayo isitho izicubu.

Inhlanganisela nezinye izidakamizwa

Benzathine benzylpenicillin (umyalelo ngqo njengoba kukhonjisiwe) baphinde baxhumane nezinye izidakamizwa. Kanjalo benzylpenicillin kungase kudingeke izinyathelo ezilandelayo: a synergistic, abasiphikisayo futhi bacteriostatic.

Ngaphezu kwalokho, izidakamizwa kwandisa ukuphumelela izidakamizwa, okuqondene anticoagulants engesobala. Futhi kunciphisa ukusebenza kwe ethinyl estradiol kanye nezindlela zokuvimbela ukukhulelwa ahlukahlukene ngomlomo.

Sebenzisa kanye ama-NSAID, allopurinol, isisu imiphumela enciphile uketshezi ijabulise futhi ukwanda isithako esisebenzayo. Ngaphezu kwalokho, allopurinol kakhulu kwandisa ingozi komzimba.

izinyathelo zokuqapha

Ngempela phambi umjovo wokuqala kuyadingeka ukuze aspirate. Uma izidakamizwa ngephutha singena imithambo yegazi, kungase kubangele ischemia noma embolism. Ngaphezu kwalokho, kungase kube umuzwa ukukhathazeka, ukucindezeleka, lezivakashi angaboni kahle.

Ezimweni lapho okudingeka uyenze ngemijovo emibili ngesikhathi, umuthi iqondiswa izingalo ezahlukene noma ezinqeni.

Lapho ukubonakaliswa yokuqala ukwelashwa iguliswa kumele kuphazamisekile ngokushesha. Ngokusho izimo Udokotela angase anikeze isiguli imithi yokungezwani komzimba.

Ngokuvamile nge benzylpenicillin ukhombe "Levorinum" noma "Nystatin", njengoba kukhona ingozi izifo fungal. Ngakho-ke akuyona yokwelapha eside isidakamizwa kungenzeka okusithiyayo of microflora emathunjini okudala amavithamini B. Kule ndaba, kungaba zaphathwa ekuphathweni esicutshini yalezi amavithamini.

Izixwayiso

Benzathine benzylpenicillin babelwe ngokuqapha ezigulini ngilugcinile ezihlukahlukene umsebenzi izinso, kukhona nezici ezithile ukuze ukubonakaliswa nomzimba, ngozwelo eliphezulu ukuze isithako esebenzayo. Isinqumo sokugcina njalo ngowamagunya udokotela, ubani okufanele ukwazi umlando isiguli sakhe.

Akunconyelwe izidakamizwa ekwelapheni neurosyphilis, kusukela lesi sifo awutholakali emakamu oyifunayo lomcebo asebenzayo igazi lesiguli.

analogs

Zikhona nezinye izidakamizwa ukuthi nomphumela ofanayo njengoba benzathine benzylpenicillin. Analogs Yiqiniso, futhi uphakathi kwabantu abangenalo leli penicillin akuzange kusize. Sibala edume kakhulu futhi ngempumelelo:

• "Gramoks-D" - ikhiqizwa ngesimo powder senzelwe zokuzalela kanye nokuphathwa ngomlomo.
• "Amosin" - ikhiqizwa amaphilisi, amaphilisi kanye powder kwezokuphatha ngomlomo.
• "Ingxibongo" - senziwa ngesimo isiraphu.
• "Hikontsil" - etholakalayo ngesimo powder kanye amaphilisi kwezokuphatha ngomlomo.
• Azlocillin sodium usawoti - izidakamizwa oluyimpuphu kusukela ezivuma isixazululo umjovo emthanjeni.
• "Ampicillin" - itholakala amaphilisi, amaphilisi, granules, yakamuva wenze slurry, futhi kuthathwa ngomlomo.
• "Ekobol" - ekhiqizwa amaphilisi.
• "Ospamoks" - senziwa ngesimo amaphilisi, amaphilisi kanye powder kwezokuphatha ngomlomo.
• "Phenoxymethylpenicillin" - itholakala amaphilisi, dragees, elimbudumbudu futhi izimpushana.
• "Inkanyezi-Pen" - senziwa ngesimo granules, okuyinto buhlanjululwe futhi kuthathwe ngomlomo.
• "Oxacillin" - senziwa ngesimo amaphilisi, amaphilisi, impuphu, kusukela lapho, isixazululo umjovo.
• "Standatsillin" - itholakala amaphilisi.
• Carbenicillin disodium usawoti - ikhiqizwa ifomu powder womshini isixazululo umjovo.

Ngakho, naphezu ukusetshenziswa kuqhathaniswa eside zomuthi kwezokwelapha, wayesalokhu uhlala omunye ejenti ephumelela kunazo ngokumelene ezihlukahlukene nezifo.