Antiseptic iMpi Okokuqala Umhlaba kokusisiza ukuba sibhekane nesimo bacterium-antibiotic-resistant

Trypaflavine - kuyinto isinqandakuvunda, eyayisetshenziswa kabanzi ekuqaleni kwekhulu elidlule. Nge ukutholakala nge-penicillin akuzange yasala dengwane, kodwa manje angakwazi ukusiza ukuxazulula inkinga ka ukukhula kwamagciwane-antibiotic nemithi, okuyinto avamise ukubizwa ngokuthi Anenkani. Ngisho ngaphezulu ngokumangalisayo, trypaflavine, ngokusobala kwandisa ukuzivikela komzimba ukuze amagciwane, ekuvikeleni amakhaza, futhi izifo mhlawumbe lubucayi kakhudlwana ezibangelwa amagciwane.

Kuvulwa usosayensi German

Usosayensi omkhulu German uPawulu Erich ngo-1912 yathola ukuthi Acriflavinium chloride, eyaziwa ngokuthi trypaflavine kungaba ukwelapha izifo lapho isetshenziswa ngaphansi kwesikhumba. It iye yasetshenziswa ekwelapheni sobuthongo e-Afrika eningizimu yeSahara, ukuze ingangenwa amagciwane amanxeba ngesikhathi seMpi Yezwe Yokuqala, ngisho emthanjeni ngokumelene isipatsholo.

nocwaningo lwanamuhla

Dr Michael Ganter we Hudson Institute yase-Australia i-Medical Research ukholelwa ukuthi lesi sakhiwo usenelungelo ukuba sibe khona, ukuhlinzeka enye indlela asebenzelana ngayo ligciwane lelingena ziye zafunda ukumelana nemithi ajwayele ukusetshenziswa. Ganter umsunguli abaphezulu cwaningo, okuyinto ubufakazi bokuthi ngemithamo emincane kakhulu trypaflavine ukukhuthaza amasosha omzimba kumaseli cultured, ekuthuthukiseni nekhono lawo lokulwa namagciwane.

"Siye aboniswe ngokokuqala ukuthi trypaflavine ngu sesibopho ukuthobisa DNA yeselula, ungakwazi agqugquzele isimiso sokuzivikela ezifweni, okubangela impendulo enamandla ebangeni engase ezibanzi kwamagciwane," - Ganter esitatimendeni.

umbhali Okokuqala Dr. Pepin Zhenevera we Hudson Institute wanezela: "Ucwaningo lwethu lubonisa ukuthi trypaflavine kuvusa omzimba omuntu kunokuba nje ukubulala amagciwane. Kucatshangwa ukuthi lokhu kungasho ukuthi leli gciwane ngeke ishintshe futhi ziyamelana nemithi izidakamizwa. Ngakho-ke trypaflavine kungaba okunye ezingaba nemithi ekhona. "

Ngisho ngaphezulu Akumangalisi ukuthi ukwanda amasosha omzimba kudlulela ekulweni amagciwane. Ganter nokubambisana abalobi yakhe ukuphakamisa njengesibonelo herpes igciwane, ngokumelene okuyinto trypaflavine kungaba wusizo ngoba singasebenza ku-site flash njengoba nje babenza ngaphambili amanxeba.

kungenzeka ngokusebenzisa

Trypaflavine kusho luwushevu uma udle phakathi wokugaya ukudla bese izinhlelo zokuphefumula yomzimba, kodwa Ganter uthi nesanda amasosha omzimba, kubonakala, siyenzeka at ngemithamo ukuthi kukhona ephansi kakhulu kunalokho leyo obukwazi umonakalo. Ngenxa yalokho, wayecabanga, kungenzeka ukusebenzisa nesifutho acinene ukuletha umthamo encane yezidakamizwa acinene mucosa amaseli bese ukukhanya ukuthi bazonibulala ngegciwane engenhla zokuphefumula. Uyokwazi ukuvikela amagciwane omkhuhlane ngokumelene, ngisho nokusindisa ukuphila uma kwenzeka kwaqubuka ezifana SARS.

Trypaflavine kubonakala ishiywe esetshenziselwa abaphathi emthanjeni ngoba izidakamizwa ukuhlala egazini usakaze isikhathi esifushane. Noma kunjalo, umphumela salo isikhathi eside lapho isetshenziswa esikhumbeni, futhi Ganter osola ukuthi Kuyokwenzeka okufanayo ngokuba ipheshana zokuphefumula, nakuba zokwelapha ungazange sezenziwe.

Revival trypaflavine kungenzeka ngokwengxenye ngenxa kwi-Inthanethi, ngoba imisebenzi German yesayensi ekuqaleni kwekhulu lama-20, isiyatholakala kalula ukuba abacwaningi emhlabeni wonke, futhi zinikeza isiqondiso ewusizo kakhulu ososayensi yesimanje.