Analogs "Ksarelto": intengo, yokusetshenziswa

Omunye izidakamizwa, elingelakwaJuda iqembu kwemithi ejenti anticoagulant, umuthi "Ksarelto". Lesi sidakamizwa kuvimbela isici Xa, futhi-ke, ngesikhathi, kuyinto ingxenye prothrombin Activator futhi kwenye yezingxenye ukuhlinzeka ngesikhathi esifanele igazi coagulation (izakhiwo ezinjalo futhi analogue "Ksarelto").

Namuhla kwenziwe imizamo eminingi iyize ukuhoxisa izidakamizwa, okuzokwenza nomphumela ofanayo futhi kanjalo unikeze ubuncane amathuba okuba nemiphumela engemihle. Ngemva umzamo nesikhathi esiningi amaningi umfuziselo uyakufanelekela - isidakamizwa "Pradaksa". Umuthi - kuphela esikhundleni ukuthi ngokugcwele ingasetshenziswa esikhundleni "Ksarelto" ukulungiselela. izici zalo cishe ezifanayo okungenhla, umehluko kuphela - isithako okuqukethwe okusebenzayo, okuyinto kuzo zombili amalungiselelo kuyinto rivaroxaban.

pharmacodynamics

Zonke analogue "Ksarelto" nomphumela ofanayo. Into kuphela bayehluka - inkomba ambalwa kanye qualitative amathuba okuba nemiphumela engemihle. Okuwukuphela Analogue njengabawufanelekele izidakamizwa, okuyinto kunomphumela ofanayo kuso, buyisidakamizwa "Pradaksa".

Lesi sidakamizwa futhi okulingana yayo Russian of "Ksarelto" kukhona ngqo izidakamizwa abakhethayo kakhulu ukuthi zivimbela isenzo Factor Xa, okusho zivimbela ke. Lesi sidakamizwa has a bioavailability okusezingeni eliphezulu temlomo, umzila Nokho enteral yokuphathwa kungumongo ke.

indiba ekulu ekuhlalisaneni kubangela coagulation isici X kusebenze kudlala okwalandela biotransformation isici Xa nge zangaphakathi nezangaphandle coagulation endleleni.

ubufakazi

Ngokuvamile, analogs "Ksarelto" nokulungiselelwa ngokwalo lisetshenziswa ezimweni ezilandelayo:

• Izinhlelo ezivimbayo futhi prophylaxis unhlangothi.
• Izinhlelo ezivimbayo futhi esiqoshiwe embolism letindzala.
  
  (Ezimweni ezinjalo, nomuthi kuboniswa in iziguli fibrillation atrial, okuyinto ayinawo umsuka valvular.)

• Ukususwa noma zokuvimbela wokufaka we deep vein thrombi.
• Ukuvimbela yokuphindela embolism yamaphaphu.

Izidakamizwa "Pradaksa", okuyinto efana, nalo wabonisa nokuvimbela izenzakalo emithambo yegazi thromboembolic ezigulini eziye zabhekana ukuhlinzwa ukuze esikhundleni omunye emalungeni nasemilenzeni aphansi.

Izimo

Noma yimuphi okulingana Russian "Ksarelto" has Izimo ezilandelayo (bangakwazi ukuba abahlukile, kodwa kuphela ngezinga elincane):

• ukuzwela noma ingozi kuwukubonakaliswa komzimba nezinto izinto eziqukethwe nomuthi;
• ukopha asebenzayo ezithinta informativeness onohlonze ngu luhlolo emitholampilo (isb, ukopha intracavitary noma ukopha ebuchosheni);

• isimo lapho kukhona amathuba ukopha ivolumu, isib, ngesikhathi esebenzayo isilonda izinqubo pheshana emathunjini;
• ukwelashwa ejenti okuyinto ifa izakhiwo ezifanayo - ekuvimbeleni coagulation;
• usebenzisa heparin unfractionated umthamo ezidingekayo ukusebenza eyanelisayo we ipayipi;
• izifo ezihlukahlukene isibindi, ukuthuthukiswa zazo ingadala ukopha of omsakazo ezihlukahlukene;
• konke nozakwabo "Ksarelto" kuthiwa contraindicated in iziguli esingamahlalakhona kwezinso, okwenzeka kunoma iyiphi isigaba;
• zokungezwani ne-lactose, okuqukethwe enganele galactose emzimbeni;
• nokukhulelwa kanye lactation;
• futhi phezu izidakamizwa futhi analogs ezihlukahlukene "Ksarelto" kukhona umkhawulo yobudala 18+.

Isigaba lwabantu kungathatha lokhu izidakamizwa ngokuqapha futhi ngaphansi kokuqondisa onguchwepheshe

Ngokuqapha futhi ngaphansi kokuqondisa kukadokotela uncoma ukusetshenziswa "Ksarelto" yokusetshenziswa (njengoba analogue) kulezi zimo ezilandelayo:

• iziguli iphathwa abangenawo amathuba ukopha kumiswa;
• esanda kushintshwa isifo esidalwa yizilonda emathunjini sibe kokuba nezici ezithile ingase ibuye ngamandla ngemva;
• ekwelapheni ukwehluleka kwezinso ntshashintshe lihambisana izidakamizwa ukuthi ukwandisa okuqukethwe rivaroxaban emzimbeni wesiguli;
• Iziguli ezelashwayo izidakamizwa uyakwazi ekuthuthukiseni hemostasis;
• amalungiselelo okuyinto bayakwazi okwandisa ezingeni rivaroxaban, isib, izidakamizwa antifungal iqembu azole;
• izibhebhe izidakamizwa kanye Analogue "Ksarelto" is contraindicated in iziguli HIV, uma nje wathatha ezihlukahlukene protease inhibitor igciwane.

Ukuphuza ngenkathi bekhulelwe nangenkathi bencelisa

Kuze kube manje, it is akunqunywa ngokunembile, njengoba ithonya "Ksarelto" analogue zomuthi ku nephephe kwabesifazane abakhulelwe.

Ukuhlolwa yayiqhutshelwa ku izilwane zokucwaninga baye babonisa ubuthi liphinyiselwe we ketshezi esebenzayo ekulungisweni ku eziphilayo umama okhulelwe, njengoba izidakamizwa kubangela ubuthi ezinzima okuzala ka umzimba female.

Ngokusho okutholakele laboratory, lesi sidakamizwa "Ksarelto" Analogue ukuthi kuyafana kubo yesenzo kwemithi unekhono ukuwela yi-placenta, ngakho izidakamizwa is contraindicated.

Futhi ngesikhathi kwesicelo "Ksarelto" abesifazane akufanele bayakhohlwa izinyathelo ngempumelelo inzalo, kusukela ekuhlaleni kwesisu, okuhambisana izinga lokushintshisana zomuthi, kungaba nomthelela wokukhula kwengane esiswini.

izahlulelo Inhloso ngomphumela zomuthi esetshenziswa esikhathini lactation, okwamanje awukho, kodwa izifundo laboratory e izilwane zokucwaninga basikisela ukuthi imfuyo asebenzayo - rivaroxaban - unekhono ukugaya hhayi excreted e ngobisi lwebele. Ngakho-ke, ibele kufanele alahle ukusetshenziswa kwezidakamizwa.

Ngokusekelwe eyanikezwa izifundo laboratory, singasho ukuthi rivaroxaban akuphazamisi ikhono ephilayo ovuthiwe ngokobulili ukudala inzalo iphila e amagundane, kodwa abantu lolu hlobo ucwaningo sezenziwe.

Umzimba nokuqeda indlela

Ukuze reception enteral kunezindlela ezintathu yokuzalanisa, okuyinto zivumelana ingxenye eyodwa kwezintathu lonke inani izidakamizwa ezingekho akheka yilezi:

• excretion urinary;
• excretion endleni yabantu abanaleli;
• ukuqedwa nge kwezinso excretion umugqa (kuleli cala, cishe azibambeki akheka futhi iqedwe ngefomu unmodified).

Biotransformation rivaroksaba eyenziwa izindlela ukuthi bazimele abekho uhlelo cytochrome.

The main indlela - the namachibi leqembu morpholino futhi ukunwetshwa izibopho amide ngamanzi.

Ucwaningo olwenziwa ngaphandle kwesibeletho, ongahlulela labo ukuthi rivaroxaban luyisisekelo P-glycoprotein futhi iprotheni enikeza ukumelana nezifo webele oncological.

Ngokuvamile, ukususwa metabolites Kwenziwa ngesikhathi amahora 5-9.

side effects

Uthi imiyalelo ukulungiselela ukusetshenziswa: analogue "Ksarelto" noma imithi self kufanele athathwe kuphela kadokotela. Kusukela endulo, iziqondiso ngokwayo likuchaza ngokuningiliziwe Isikali zomuthi, noma analogue yayo. Qiniseka ukufunda yokwamukela isiqondiso!

Ngezansi ibonisa zonke izinqubo engadingeki futhi ukusabela eyayintula izidakamizwa "Ksarelto" analogs. Inani amaphilisi - ruble 900. Kuyinto engabizi uma ucabangela ukuthi iningi amathuba okuba nemiphumela engemihle kukhona kilomlayo.

• imiphumela engemihle iye yabonakala lapho ukuhlola igazi uhlelo lymph, kukhona sokuntuleka kwegazi kanye thrombocythemia, okuyinto avele njalo.
• Tachycardia - ukusabela kuphela enqabayo uma nithatha le izidakamizwa.
• Ukopha.

Lawa amaphuzu contraindications lesi sidakamizwa "Ksarelto" imfundiso.

Analogs yalesi izidakamizwa kungadala ukungasebenzi ipheshana wokugaya ukudla: ukopha ubuhlungu ezindaweni ezithile, izimpawu dyspeptic, ngezinye izikhathi - nomlomo owomile.

Ngenxa ukwethulwa ukusabela wendawo rivaroxaban singenzeka: imfiva, ukuvuvukala kusayithi umjovo lapho zaphathwa parenterally indlela, ubuthakathaka kanye umkhuhlane.

Ukuvela kilelihlelo neqhaza ukulungiswa "Ksarelto" nozakwabo. I inani lentengo lomuthi, njengoba umthetho, indinganiso kuwo wonke amaketanga ekhemisi.

Izindlela Yokusebenzisa kanye Isikali

Imininingwane eyengeziwe mayelana reception lesifanele anganikeza emuthini noma ngokuphelele "Ksarelto" imfundiso. Analogue zomuthi kule ukuhlonipha akukona bahluke.

Lesi sidakamizwa itholakala ifomu tablet, ngakho iphilisi esithathwayo enterally. Uma isiguli ngasizathu simbe ayikwazi ukugwinya ithebhulethi - ke kungenziwa kutsho futhi ixubene uketshezi efanelekayo (itiye, amanzi).

Ngemva kokuthola lokhu izidakamizwa kufanele ngokushesha ulandele ukudla.

ukweqisa izidakamizwa

Ukwahluleka okuthobela nanoma kwezinkambiso reception "Ksarelto" ukweqisa izidakamizwa kungenzeka, okuyinto abaphathwa ngenhlonipho ngayo symptomatically, njengoba izidakamizwa has a yokuvimbela ethize.

Ukuze kuncishiswe adsorption zomuthi emathunjini amancane angaba inoma uluphi sorbent, ezifana carbon isebenze. Futhi ukusheshisa excretion of metabolites kudingekile ukunikeza diuresis bephoqeleka, okuyinto eyenziwa nge ukusetshenziswa esiningi uketshezi ukusetshenziswa isisu.

amanani

Kuye umkhiqizi, intengo "Ksarelto" izidakamizwa kuhluka ruble 899,00. amaphilisi 10 aqukethe 10 mg isithako esisebenzayo, ukuze 1740,49 RUB.

Iphakheji, lapho 30 zithutha, angathengwa ruble 3300,00.

Iphakheji ngobukhulu iqukethe amaphilisi 100, kubiza ruble 8600.

Intengo Yemfihlo "Pradaksa" izidakamizwa kuncike okuqukethwe ambalwa isithako esisebenzayo capsule ngayinye:

• 75 mg - 716,00 deda;.
• 110 mg - 1574,00 deda;.
• 150 mg - 1676,00 deda.