Umkhiqizo "Amikacin": izibuyekezo odokotela

Kanjani umuthi ezifana "Amikacin" (isibhamu)? Impendulo ukuphumelela izidakamizwa kuchaziwe ngezansi. Lesi sihloko sibuye kuveza izinkomba for ukusetshenziswa ithuluzi, izici zayo zokwelapha nezindlela zokusebenzisa.

Ifomu, ukwakheka

Ngayiphi ifomu ekhiqizwa imithi "Amikacin"? Izimpendulo libike ukuthi lo ejenti angathengwa njengoba isixazululo kucace, ezinemibala kancane noma kungekho nto enemibala emihle, okuyinto kwezokuphatha emthanjeni kanye nokuphathwa esicutshini.

Isici esebenzayo ye ekwakhiweni amikacin uvezwa uhlobo sulfate. Futhi izingxenye ikhambi kufaka izithako ezifana alulaze sulfuric acid, i-sodium bisulfite, amanzi d / u kanye sodium citrate d / u.

Ngo ukudayiswa wayebheka izidakamizwa iza izitsha eziyisikhombisa ezenziwe ngengilazi, okuyinto Agcwele emabhokisini ephepheni.

Asinakusho ukuthi izidakamizwa "Amikacin", ukubuyekezwa zazo zingaphezu omuhle, zingatholakala ngesimo powder senzelwe isixazululo umjovo.

mshini wezenzo

Kuyini "Amikacin"? Uphenyo odokotela bethi ejenti semi zokwenziwa ngemithi elwa namagciwane, elingelakwaJuda iqembu aminoglycosides abese ethatha isinyathelo amagciwane.

Kubhekwe umuthi kakhulu asebenzayo ngokumelene igremu-negative nezilwanyana ezincane aerobic namagciwane athile Gram-HIV. Kufanele kuqashelwe ukuthi kukho abonise ezinhle ukuzinza anaerobic nezilwanyana ezincane.

Izidakamizwa "Amikacin" ukuthi libuyekeza angashiya zonke iziguli, akaphelelwa umsebenzi wayo bedle enzyme ukuthi okunqanda nezinye aminoglycosides, futhi kungase futhi zibulale zakulezi Pseudomonas aeruginosa, okuyinto abonise ukumelana gentamicin, tobramycin futhi netilmicin.

isixazululo Kinetic ikhono

ikhambi "Amikacin" ukusivumela? Izibuyekezo babike ukuthi ngemva kokuphathwa esicutshini zomuthi is egxile ngokuphelele futhi ngokushesha. Isilinganiso lokuhlushwa oqabulayo ketshezi asebenzayo ithuluzi zigcinwe amahora 11-12.

"Amikacin" lubopha ukuba plasma amaprotheni, it is kahle kwasakazwa nokusaketshezi extracellular ezitholakala uketshezi bronchial, umchamo, isikhwehlela, Bile, amahlaya aqueous izitho ezibukwayo, ubisi lwebele, futhi cerebrospinal fluid.

Lesi sidakamizwa akuyona akheka. It is excreted ngu izinso ngefomu zinjalo.

Izinkomba kwezokuphatha zomuthi

Kwezinye izimo, izidakamizwa zisebenzisa "Amikacin" (isibhamu)? Izingane (impendulo mayelana naleli thuluzi, kusale iziguli eziningi) kanye nabantu abadala izidakamizwa ezinqunyiwe zezifo ezithathelwanayo namakhambi ukuvuvukala, okuyinto zibangelwa Gram-negative amagciwane noma izinhlangano zabo:

• sepsis;
• izifo yaleli pheshana zokuphefumula;
• CNS izifo (kuhlanganise meningitis);
• endocarditis ukonakala;
• besisu ingaphakathi ukutheleleka;
• ukutheleleka (ubomvu) isikhumba futhi izicubu zomzimba ezithambile;
• Pheshana urinary ukutheleleka (kuhlanganise cystitis, pyelonephritis, urethritis);
• ipheshana biliary;
• nilimaza ukutheleleka;
• izifo amalunga namathambo;
• ukutheleleka nasezinkingeni ezilandela ngemva kokuhlinzwa.

Uvala ukwethulwa

Kwezinye izimo, awukwazi ukungena izidakamizwa "Amikacin"? Isifo samaphaphu (ukubuyekezwa imithi tibalwe lapha ngentasi), lokhu izidakamizwa awukudla kahle. Nokho, empeleni akufanele kutsi sisetjentiselwe lapho:

• ukhulelwe;
• neuritis we emsipheni sokuzwa ;
• ezinzima ezingamahlalakhona ukwehluleka kwezinso ezifana uremia futhi azotemia;
• sensitivity high ukuze ketshezi izidakamizwa;
• sensitivity high kwamanye aminoglycosides.

Ngokunakekela lesi sakhiwo kumele sisetshenziswe ezinsaneni, ukuntuleka kwamanzi emzimbeni, isifo i-Parkinson futhi botulism, ukwehluleka kwezinso, ezigulini esezikhulile, esikhathini ezisanda kubelethwa, ngesikhathi lactation, futhi ezizalwa ngaphambi kwesikhathi.

Izidakamizwa "Amikacin": isitatimende

Izibuyekezo babike ukuthi kangcono kusebenta oqabulayo izidakamizwa umbuzo kumele isetshenziswe kuphela kuma-oda kadokotela.

Lo muthi iqondiswa ngemithambo yegazi noma intramuscularly ukuba abadala nezingane, kusukela koneminyaka engamashumi ayisithupha ubudala.

Umthamo esiphezulu sale-antibiotic abadala kuyinto 15 mg / kg ngosuku. Isikhathi ukwelashwa ngaphansi ukucatshangelwa kusho lapho zaphathwa ngemithambo yegazi kuyinto sonto, futhi esicutshini - izinsuku 9-10.

Ngokuqondene nabantwana, umthamo kokuqala eyodwa izidakamizwa ngabo-10 mg / kg, bese - 7.5 mg / kg njalo emahoreni 20-24.

Ukuze abaphathi emthanjeni, izidakamizwa esebenzayo kufanele kuqala buhlanjululwe 5% dextrose noma 0.9% isixazululo sodium chloride.

side effects

Uma usebenzisa izidakamizwa "Amikacin" kungenzeka ezifana side effects njengoba isicanucanu, ukozela, ukuhlanza, ikhanda elibuhlungu, kahle isibindi umsebenzi, ukuntuleka kwegazi emzimbeni, ototoxicity, nephrotoxicity, ukuqubuka kwesikhumba, ubuhlungu ngesikhathi umjovo site, ukulunywa, dermatitis, isikhumba ububomvu, phlebitis, imfiva , periphlebitis, angioedema.

Izibuyekezo

Izibuyekezo Ochwepheshe mayelana izidakamizwa "Amikacin" bathi Ezikhathini eziningi lomuthi lusebenza kahle kakhulu. Kuyinto kahle ukulwa ezifweni ezihlukahlukene futhi kusiza kakhulu isimo kanzima iziguli. Nokho, kufanele kuphawulwe ukuthi odokotela abaningi ukhathazekile ngokuthi imithi kubhekwe kubangela eminingi engemihle. Kule ndaba, ochwepheshe abaningi besabe linqume lokhu izidakamizwa futhi esikhundleni salo analogue ephephile.