LDH - kuyini? Izizathu LDH okwandisa

imithi yesimanje akusho yima, nsuku zonke uyaqhubeka ukhula. sebuningini assays ukusetshenziselwa ukuxilonga izifo ezihlukahlukene. Umuntu ovamile kunzima ukuqonda konke amagama abo. Ngokwesibonelo, cabangela izinkondlo, LDH. Kuyini, kwaba yilowo nalowo muntu emgwaqweni akazi, kodwa le ndlela yocwaningo, odokotela basebenzisa ngokuvamile lokho kwanele. Yini isifo singalapheki ihlonzwe usebenzisa LDH ukuhlaziywa kunalokho libhekene ezingeni egazini lenyuke noma kwehle. Ake siphenye.

Kuyini LDH

Okokuqala sidinga ukuba siqonde ukuthi kufihlwe ngaphansi ongaziwa, Uma unganakile, i LDH emelela. Lactate - enzyme akhethekile, okuyinto izinqubo ebalulekile namachibi glucose futhi kukhiqizwe acidosis acid. umzimba womuntu omdala yalolu ketshezi akakwazi buthelela. Ngenxa izinqubo zemvelo uyabhujiswa futhi excreted. Nokho, kukhona ezinye izifo libhekene nenkinga yezinga oluphakeme LDH egazini. Lokhu kwenzeka ezimweni lapho izicubu ezonakele noma kumaseli emzimbeni. Yingakho LDH - umaka kubaluleke kakhulu ngawo afeze ukuhlola.

izinhlobo LDH

Ukuthi kuyini, sesikubonile esiphethweni, kodwa kufanelekile ukuba ngicacise ezinye izici zalesi enzyme. Njengoba wazi, anakho amafomu emihlanu, okuyinto ihluke nomunye kuphela isakhiwo cell. Ngaphezu kwalokho, ngamunye zalezi zinhlobo bagxila emizimbeni ehlukile.

Ukuguqulwa-enzyme ebizwa ngokuthi lactate dehydrogenase isoenzymes. Ngakho, ababonakali ngezikhundla:

• LDH 1 - wansuku zonke izicubu ubuchopho kanye senhliziyo esilimele.
• LDH 2 - ke aqukethe egazi (erythrocyte, izinhlayiya zegazi), ne-isibindi.
• LDH 3 - eziqukethwe imisipha lwamathambo, e kwamanyikwe futhi yegilo nezindlala, kanye ezicutshini kwezitho ezifana emaphashini, ubende kanye nezindlala adrenal.
• LDH 4 - evelele kwezitho efanayo njengoba LDH 3, futhi ngaphezu kwalokho, iduna germ cells, yi-placenta, isibindi, futhi granulocytes.
• LDG 5 - iningi lokhu isoenzyme ezitholakala kwezicubu imisipha lwamathambo futhi isibindi, kodwa ngaphandle kwalokho, kuyisici esihlupha izitho efanayo, futhi LDH 4.

kuyinsakavukela

Ngakho, thina esiphethweni lokho LDH. Kuyinsakavukela lokhu enzyme kuhlukile abadala kanye nezingane kanye abesilisa nabesifazane. Okokuqala, yini izinkomba imizwa kubhekwa njengento evamile izingane.

• Ngosuku lokuqala zokuphila enzyme lokuhlushwa kufanele kube 22.1 mkkat / l.
• Ngakusasa izinsuku ezine liyophuma ezingeni 28,9.
• Kusukela ngesonto izinyanga eziyisithupha ubudala futhi LDH eyehlisiwe. Ukukala kuyinto 16.3 mkkat / l.
• Ngakusasa izinyanga 6 lokube nawo ezingeni lekuphila inyuka kancane futhi, lesi sikhathi ukuze uphawu 18.3.
• Ngemva ekukhishweni ngonyaka owodwa futhi kuze kube iminyaka emithathu ka LDH ezinganeni kufanele kube 14.2 mkkat / l.
• Kusukela ngineminyaka engu-indices eziyisikhombisa nabesifazane ezahlukene uqale zehluke. Boys ezingeni kungokwemvelo kufanele kube 12.7 mkkat / l, futhi amantombazane - 9,67.
• Ngemva kweminyaka engu-nantathu of inkomba enzyme uzinzile ezingeni 11.4 e abafana abadala. lokhu kulinganisela kancane kuyehla, kanti kuso sonke isikhathi kuba 7,27 mkkat / L e amantombazane nabesifazane.

LDH igazi. Kuyini lokhu?

Njengoba sekushiwo, kuba umaka esihle ukuze kuhlonzwe zezinkinga ezihlukahlukene zomzimba. Kodwa kuyini nokuthi ukuhlaziywa kwamakhemikhali LDH? Lokhu indlela yokuhlola igazi, ngawo ungakwazi ukunquma inani lactate egazini. Lapho kukhona isidingo azihlole?

izinkomba ngoba

LDH Kwenziwa esimweni lapho kukhona izinsolo ukuthi izitho abalimala noma ohlelweni lwabo. It izicubu ukulimala kuphakamisa ngokuvuswa enzyme igazi. Lokhu kuyiqiniso ikakhulukazi of the izicubu zenhliziyo, ubuchopho, iphaphu, izinso, imisipha lwamathambo.

Uma usola ukuthi ube ne-melanoma futhi ukuqhuba igazi lactate dehydrogenase. Kusho ukuthini? Iqiniso lokuthi leli ukuhlaziywa lembula Ukudlulela esikhathini kwezitho zamanzi. Lokhu izifundo indlela e-melanoma akakwazi ngokuthi ethile, kodwa ivumela ukuqapha isimo isiguli in kwesikhathi nasezinkingeni ezilandela ngemva kokuhlinzwa, futhi ukucacisa komqondo nezinga lokukhula kwengane lwesimila. Ngaphezu kwalokho, uma i ngempumelelo yokwelapha enzyme igazi liyancipha, ngakho-ke, lalomaka usetshenziselwa ukukhomba Dynamics ekwelapheni.

Ukulungiselela nokulethwa ukuhlaziywa

Ngaphambi ofeza ukuhlaziywa, isiguli kufanele uzilungiselele ke. Cishe, udokotela wakho uzokweluleka ayeke ukuthatha imithi ethile, njengoba kungase kuthinte ukunemba imiphumela LDH. Kuyini, siye sabona kakade. Kodwa lokho kusho ayikwazi izinsuku ezintathu ngaphambi ukuhlaziywa? Lezi zihlanganisa i-aspirin, imithi ebulala izinzwa, ascorbic acid (uvithamini C), mitromitsin, clofibrate, procainamide, fluorides. Kufanele uyeke utshwala, ngoba kungaba ukwandisa ezingeni enzyme wafunda.

Njengoba ukuhlaziywa

Igazi amasampuli kwenziwa emithanjeni abadala ku izingalo nesibaya nge inaliti ekhethekile. Ukuze uthathe nawe ngamaphuzu akuleso izingane noma abantwana, sebenzisa i-Lancet. Ngaphezu imithambo udokotela kungathatha igazi kusukela ingxenye yendlebe ethambile, lezwaneni olukhulu noma isithende. Beka ucingo icutshungulwe futhi emva inqubo, lapho isetshenziswa ngebhandeshi ingcindezi. Ukulandela inqubo kungenzeka ubuhlungu ezincane.

amasampula egazi zafakwa tube ukuhlolwa noma aku-slide ngesibonakhulu. Ngo-laboratory, indaba eqoqwe isethwe ku Centrifuge ekhethekile, lapho serum lwabelwe yilo. Ngakho, sokunquma ezingeni enzyme igazi.

Yini okufanele ibe amagugu sitjhwile. Inani enzyme kungenzeka kokubili anda futhi yehlise. Yini-ke iqhaza?

Izizathu ezingeni anda LDH

Uma imiphumela yokuhlolwa ibonisa ukwanda LDH, kubalulekile ukuba sifune Lo msindo ubangelwa. Izinga eliphezulu yayo wathi ukuthi kukhona umonakalo kunoma izicubu. Uma imiphumela ibonisa ukwanda inani ezingaphezu kweyodwa isozyme nokuningi, kungase kubonise ukuthi kukhona eziningi iziyaluyalu emzimbeni. Kwenzeka ukuthi imiphumela yokuhlolwa ibonisani kukhuphuke izinga yazo zonke izinhlobo ezinhlanu LDH. Kulokhu, singakhuluma lezo zitho zomzimba eziningi.

Nokho, uphethwe alikwazi, zisekelwe kuphela ezingeni LDH. Ukuhlolwa kwegazi izinguquko inani isoenzymes kusiza kunalokho, ukucaciseleka yakhe. Naphezu kwakho konke lokhu ochwepheshe Kufanele wazi ukuthi yimuphi iziphathimandla ukuba banake kwasekuqaleni, uma aphakeme LDH. izizathu ezingase kanje:

• Stroke.
• isilethikusebenza. Kulokhu, ezingeni ongama amahora 36-55 emuva kwalesi sigameko. Kuvele esengeziwe enzyme ibizwa walondolozwa ukuze izinsuku ezingu-3-10.
• infarction yamaphaphu. izimpawu sakhe sokuqala - kuyinto ubuhlungu endaweni esifubeni. Khona-ke, futhi wakhulela amazinga-enzyme.
• wamathumbu infarction.
• izinso myocardial, pyelonephritis.
• Congestive yokumelwa yinhliziyo.
• Isibindi zokugula futhi ibe imbangela ezingeni anda LDH. Kusho ukuthini? Ngokuyinhloko inani le enzayimu kwandisa ne kwesibindi, izicubu izinguquko ngenxa ukuluthwa utshwala, kanye acute ukusha kwesibindi kohlobo ezibangelwa amagciwane.
• Umdlavuza nazo ephelezelwa ukwanda LDH ezingeni.
• izifo igazi avuse hemolysis.
• LDH uphawu futhi pancreatitis oyingozi.
• Hypoxia, hypothermia, komzimba okukhulu.
• Lymphoma.
• Mononucleosis, okuyinto ithuthukiswe ngenxa ukutheleleka.
• meningitis okunobuthi. Ukwandisa ezingeni LDH libonisa nokuthi kunenkathi ukuthuthukiswa encephalitis.
• Sokuwohloka, imisipha yoma, ukulimala kwabo.
• ukushaqeka Obungapheli.
• Uqhekeko kanye waphuka.
• ukusha Multiple.
• Nokuquleka.
• delirium Alcoholic noma isidakamizwa.
• Eclampsia.
• Kwamanye abesifazane abakhulelwe, amazinga aphakeme LDH - isimo evamile. Kwabanye, azihlole kungase kubonise lamabutho umzanyana. Kunoma ikuphi, anda ngesilinganiso LDH - isizathu ukubona udokotela.

Njengoba sekushiwo, ezingeni elilodwa noma ngaphezulu isoenzymes ka LDH isigqugquzeli bengayi ngokwako eyabonisa esinye sezifo ngenhla. Kuyadingeka ukuba amazwe nokufeza eminye nophenyo. Liyadingeka ukucacisa umsebenzi othile isozyme ethile. Khona sizokwazi ukukhuluma ngenkinga kwasendaweni.

Ngokwesibonelo, amazinga aphezulu sezihlonziwe isoenzymes 4 no-5 LDH. Kuyini lokhu? Kunalokho, kwakukhona ukulahlekelwa kwemisipha izicubu, noma isibindi. Kodwa ukubona lokhu, kubalulekile ukuba sithole ukuhlolwa ukusebenza umzimba wesiguli.

Ngakho, umphumela LDH Assay angabhekwa kuphela lihambisana namanye izifundo. Kubalulekile futhi ukuqapha Dynamics yale nqubo, njengoba ufeza indima ebalulekile ekunqumeni izinqubo sokugembula.

ezingeni Unciphise LDH

Ngezinye izikhathi imiphumela yokuhlolwa ingabonisa ukwehla ezingeni LDH egazini. Lona umcimbi sasivumela ezingavamile elikhombisa ukuthi umzimba ngenkuthalo ezidabula ne-glucose uthola kusuka ku-ke amandla amaseli, ikakhulukazi kwemisipha.

Kwehliswe LDH zingenza nge zofuzo. Mhlawumbe amabili kuphela zazo. Abantu unesifo Uhlobo lokuqala, uyozizwa ukukhathala buthakathaka kwezicubu. Ukuguqula izakhi zofuzo yohlobo yesibili Awunawo izimpawu. Ukwehla LDH ezingeni ingabagulisa engayitholi ngokweqile ascorbic acid (uvithamini C).