Folic acid: side effects, kanjani ukuthatha

Ukukhulelwa yonke wesifazane - inkathi ebaluleke kakhulu yeminyaka ukuphila. Futhi indima B amavithamini ekuthuthukiseni umbungu kubaluleke kakhulu. Ziyakwazi ezidingekayo ukuze kwakhiwe evamile izinhlelo sezinzwa nezinye, cell division, inqubo hematopoiesis kanye nentuthuko evamile umbungu. Ngakho-ke kubaluleke kakhulu ngaphambi kokukhulelwa ukuqala kokuthatha lesi izidakamizwa ngokuthi "i-folic acid". Imiphumela engemihle, ukubuyekezwa kanye zonke izici isicelo wathi kusho ukuthi ngeke ukumboza kamuva kulesi sihloko.

ulwazi oluyisisekelo

Folic acid - a amanzi-encibilikayo vitamin B9. Kwakuthinta eyaqala ukutholwa ngawo-30s kwekhulu elidlule. Futhi amaphayona waqala Mehta futhi Wills. Ukutholakala kwaleli qiniso liye labizwa ngokuthi "isici Amasondo" kanye reception ngokuthi Vitamin kusiza ekwelapheni isifo sokulahlekelwa igazi e abakhulelwe abesifazane. Ngemva nje kancane kwalokho, ososayensi bakwazi ukuthola Vitamin kusuka amaqabunga isipinashi, wagibela igama "i-folic acid".

Imiphumela emibi efana kungaqali, kodwa yebo, thatha akufanele kube engalawuliwe. Ngokwemithetho yempilo ngasebenzi folic acid engena emzimbeni, nge cell ayo is kuguquka injalo asebenzayo - tetrahydrofolic acid, okuyinto kubhekwa ngesisekelo ukuze kwakhiwe i-DNA ne-RNA.

Kuyinto ebalulekile evamile nokuvuthwa kanye normoblasts megaloblasts, uhlanganyela zamagama amino acid, acid nucleic, umzimba choline, purine futhi pyrimidine. Futhi ngesikhathi sokukhulelwa edonsa izidakamizwa ukuvikela umzimba wowesifazane futhi ingane nokusondelana teratogens.

Uma esiswini, acid ngokushesha ugxile khona. Ibe metabolites esibindini. Okukhonjiswe umchamo. imiphumela emibi-folic acid avame ukuthuthukisa ngesimo komzimba.

Uchaza into akhiqizwa uhlobo amaphilisi kanye amaphilisi, efanelekayo yokwamukela kanye ingxenye sebuningini izidakamizwa Izithako zokudla.

Izinkomba kanye contraindications

amaphilisi acid folic babelwa for anaemia kubangelwa ukuntula izinto wathi emzimbeni, kanye izingxenye ukwelashwa:

• Gastroenteritis ezingamahlalakhona;
• sofuba emathunjini;
• nokuvimbela kwemizwa tube kombungu ku-fetus ngesikhathi senyanga yokuqala nokukhulelwa;
• nge sprue.

Folic acid is contraindicated uma isiguli eba hypersensitivity kuso kanye:

• e izimila anomdlavuza;
• gemosideroze;
• ukwephulwa yensimbi umzimba;
• ezimeni cobalamin ukuntula;
• malabsorption vitamin B12.

Isikali

Folic acid amalungiselelo ngokuvamile ibekezelelwe kahle, futhi ukweqisa izidakamizwa akuvamile uyalandelwa. Umthamo incike yobudala isiguli isifo zaba namandla kakhulu. Ngokwesibonelo, umuntu omdala ngosuku ezinqunyiwe oda 200 UG, ukhulelwe - 300-400 g nabancelisayo - 500 micrograms. Isikhathi yokwelapha ngokuvamile inyanga eyodwa.

Izingane kusho inikezwe umthamo ephansi - kusuka 40 kuya 200 mg, kuye ngesimo. Kwezinye izimo, amaphilisi "folic acid" side effects e izingane engaveza njengoba ukuqubuka futhi ukulunywa esikhumbeni.

Ukuze uthathe zokuvimbela nomuthi ngesilinganiso 20 noma 50 micrograms ngosuku.

izidakamizwa ekuhlanganyeleni

Naphezu ukungabi virtual amathuba okuba nemiphumela engemihle Kusafanele athobele imithetho ethile ekusebenziseni "folic acid" amaphilisi. Ngakho, it is hhayi Kunconywa ukuba bathathe imithi ezilandelayo:

• zokuvimbela inzalo ngomlomo;
• "Sulfasalazine";
• "Phenytoin";
• "Phenobarbital";
• "Primidone".

Njengoba sekushiwo, ezimweni eziningi lesi sidakamizwa is kahle ibekezelelwe, kodwa ngezinye izikhathi kungase kubonakale komzimba ezifana ukuqubuka futhi ububomvu esikhumbeni. Uma uhlangabezana lezi zimpawu, afune usizo lwezokwelapha. Yena ukhansele izidakamizwa futhi zibeka ukwelashwa lingaze.

Ngezinye izikhathi imiphumela emibi-folic acid ngesikhathi sokukhulelwa kungaphazamisa ngokwenqaba ukuthinta owesifazane ngendlela ekuseni ukugula, ukuqwasha kanye nobuhlungu anda. A ekuphathweni ezingamahlalakhona amazinga okukhishwa okwandisiwe izidakamizwa kungabangela ubuhlungu besisu, ukwephulwa kwesitulo ngisho nokuquleka.

Izixwayiso

Phakathi amalungiselelo reception equkethe i-folic acid, kufanele sikhumbule ukuthi anaemia eziyingozi ukuthatha imithi kudingeka vitamin B12 kuphela, ngoba acid kuvusa hematopoiesis futhi akuvimbeli ukuthuthukiswa yezinkinga ezithile zesimiso sezinzwa. ukusetshenziswa kakhulu isikhathi eside acid kungadala ukwehla igazi cyanocobalamin.

By the way, acid echazwe ingaphinda babelwe abameleli ubulili namandla. Uma isidoda besilisa iqukethe lemali asanele noma ngokweqile wama-chromosomes, kungashiwo okwatholakala "aneuploidy". Ngokuvamile, kuba imbangela ukungabi nenzalo wesilisa. Nciphisa ingozi yokuba lesi sifo uyokwelapha "folic acid".

Imiphumela engemihle ezingabantu, ngasendleleni, zenzeka ezimweni ezingajwayelekile, njengoba umthetho, ukulunywa kwesikhumba.

Izidakamizwa "Folacin"

Sizakuragela ukuchaza eceleni amalungiselelo equkethe i-folic acid. Ngakho, "Folacin" libhekisela eqenjini amavithamini bese kukhishelwa ngesimo amaphilisi aphuzi equkethe 5 mg Vitamin B9. Lena kunalelo umthamo wansuku zonke kwabesifazane abakhulelwe, kodwa kungezona lezo ngokweqile is excreted ku umchamo.

Wasebenzisa izidakamizwa uma ezinzima amavithamini ngokuthi, kodwa ukuvimbela it is hhayi Kunconywa ukuthatha.

iphilisi Ngokuthi kuvusa erythropoiesis, zamagama amino acid kanye choline exchange. Phakathi nenkathi yokukhulelwa, le izidakamizwa ivikela umbungu kusuka emiphumeleni elimazayo imvelo, ikhuthaza ukuthuthukiswa evamile kanye nokuvuthwa umzanyana. Kuyasiza ukwelapha futhi ngesikhathi ibele. Imiphumela emibi folic acid ekulungiseleleni "Folacin" ezimweni eziningi, akukho.

Izinkomba kanye contraindications

"Folacin" angabelwa kulezi zimo ezilandelayo:

• ekwelapheni acute folate ukuntula elihlobene ne ukungondleki;
• inqubo ukwelashwa kwegazi, okuyinto sokucasuka ethile ye wathi izidakamizwa emzimbeni;
• ekwelapheni isifo sokulahlekelwa igazi ngesikhathi sokukhulelwa noma lactation;
• ukuvimbela ukuthuthukiswa okungavamile neural tube ku-fetus esibelethweni;
• ukwelashwa eside izidakamizwa, okuyizinto folic acid abantu abamelene nani.

Njengoba sekushiwo, ejenti saziso esimisiwe, aqukethe i-folic acid ngesikhathi sokukhulelwa. Imiphumela engemihle (lokho futhi kanjani azibonakali) kusukela ukungena yabo ingatholakala kudokotela wakho. Izimo, njengoba umthetho, yilezi:

• komdlavuza ezihlukahlukene;
• cobalamin ukuntula;
• anaemia eziyingozi;
• Hypersensitivity emuthini.

Umthamo lesi sidakamizwa "Folacin"

"Folacin" iqondiswa ngomlomo. Izibhebhe ingahlukaniswa. Ukuze ekwelapheni zonke izinhlobo anaemia okuhlotshaniswa folic acid ukuntuleka kwamavithamini, ukungezwani umuthi ezithathwe umthamo 5 mg kanye ngelanga. Isikhathi yokuyelapha izinyanga 4. Ngo izinqubo ukuvuvukala kule ikholoni kanye isidakamizwa dosed ukungondleki kuya ku-15 mg ngosuku.

Ngokuba nokuvimbela kwemizwa tube kwezinso ku-fetus ngaphambi kokukhulelwa izidakamizwa esithathwayo ngesikhathi umthamo 2.5 mg ngosuku ngenyanga. Amaphilisi luqhubeke e senyanga yokuqala sokukhulelwa.

Ukuxhumana nezinye izidakamizwa

Akuvunyelwe ukwabelana izidakamizwa ngezindlela ezilandelayo:

• "Chloramphenicol";
• "Neomycin";
• "Polymyxin";
• "Tetracycline";
• "Cycloserine";
• "Phenobarbital";
• "Primidone";
• "Cholestyramine".

Ngaphambi ukwelashwa kubalulekile ukucabangela indlela ukuthi kuyoba aphendule ethile izidakamizwa i-folic acid. Imiphumela engemihle (nesicanucanu, ukuqubuka kwesikhumba) ezivele ngenxa yalokho, kungase kubonise ukuthi imithi esithathwayo kahle.

Izidakamizwa "Mamifol"

nomuthi Landelayo equkethe i-folic acid kungokwalabo iqembu vitamin amalungiselelo. Yena itholakala ngendlela amaphilisi emhlophe. Ukulungiswa kufaka i-folic acid umthamo 0.4 mg.

Ukusebenzisa synthesis wathi izindlela kuyinto olungisiwe acid acid methionine, okuyinto bakhubazekile omama abakhulelwe. Ngakho-ke, badinga ngesikhathi sokukhulelwa kusaqalwa ukuqala ukuthatha "Mamifol", lapho kukhona i-folic acid. Imiphumela engemihle evela ukusetshenziswa - njengemithi yokungezwani komzimba nokuthile, pruritus, erythema, futhi bronchospasm. Kodwa ukuthuthukisa kaningi impela.

Izinkomba kanye contraindications

Wathi ukulungiselela ingasetshenziswa kulezi zimo:

• anaemia kubangelwa folic acid ukuntula;
• nokuvimbela kwemizwa tube yokulimala umbungu.

Izimo ukusetshenziswa yilezi:

• cobalamin ukuntula;
• isimila umdlavuza;
• anaemia eziyingozi;
• ukuthambekela ukuthuthukisa komzimba.

Isikali

Umuthi inikezwa iphilisi elilodwa ngaphambi uhlela ukukhulelwa e senyanga yokuqala futhi emva ivela khona. Inkambo yokwelashwa selunenyanga.

Uphuzwe ngomlomo ngaphambi kokudla, okungcono ekuseni. Umthamo kungase kukhule uma isiguli okusezingeni eliphezulu ukuntula folate futhi anaemia uqalise.

ukweqisa izidakamizwa

Ukulungiselela "Mamifol 'ebekezelele ngokubhekakade kahle ngemithamo kuze 5 mg ngosuku. A lokuhlushwa ephakeme kungaholela okulandelayo side effects:

• iziyaluyalu isimiso sezinzwa esiyinhloko umsebenzi;
• ukwehluleka esiswini namathumbu.

Ukuze ugweme ukweqisa izidakamizwa, kufanele kuthathe kahle imithi aqukethe i-folic acid. ngokuvamile Imiphumela engemihle iyanyamalala ngemuva kwezinsuku ezimbalwa emva umthamo ukulungiswa.

Ukuxhumana nezinye izidakamizwa

Musa thatha izidakamizwa "Mamifol" ngezindlela ezilandelayo:

• "Monotreksat";
• "Sulfasalazine";
• zokuvimbela inzalo ngomlomo.

Izidakamizwa ngokumelene yisithuthwane ngokulandelana kwawo, kunalokho, kwandise isidingo folic acid.

Ezimweni ezingavamile, ohlangothini imiphumela elandelayo angagcina ngokuhamba yokwelapha:

• njengemithi yokungezwani komzimba nokuthile, obonakala njengenhlangano ukuqubuka, ububomvu kwesikhumba;
• ukubuyisa;
• isicanucanu;
• ubuhlungu epigastric;
• thuthuva ubuthongo;
• ukukhathazeka.

On okuvela kuyo noma yiziphi izinkomba ezisheshe ezingemnandi kufanele wazise udokotela wakho.

Izixwayiso

Gcina izidakamizwa esekelwe folic acid kuyadingeka ezingeni lokushisa akukho ephakeme kuka-degree angu-30 kufinyelela khona izingane esingaphansi kweminyaka emibili. Ukwakheka izidakamizwa kuhlanganisa i-lactose, ngakho-ke abakwazi zaphathwa iziguli ezinokuphazamiseka lezinceku nokwenziwa ngendlela ketshezi.

Njengoba ungase ubone ngenhla, imiphumela emibi-folic acid kuba ngempela ezingavamile, futhi bavame ukuqala lapho kukhethwe kahle umthamo. Ngakho-ke ngaphambi kokwelashwa kufanele ufunde ngokucophelela yokusetshenziswa, echaza ngokuningiliziwe zonke izinkomba kanye contraindications ithuluzi, futhi ikakhulukazi reception yakhe.

Kubalulekile ukukhumbula ukuthi udokotela kuphela angakunika umuthi kanye umthamo yayo isethi. Ukuzelapha kungaba futhi kungaholela emiphumeleni engathí sina. By endleleni, emva kokuphela ukuphila izibhebhe akufanele kuthathwe njengoba ukungayinaki izincomo kungaholela poisoning sina.

Folic acid udlala indima ebalulekile ukusebenza evamile umzimba, ngakho kufanele uqale ukuphuza imithi, ingxenye lapho ingxenye ifakiwe umsoco ngokwanele, ukucindezeleka njalo. Ungakhohlwa ukuthatha ikhambi ngesikhathi sokukhulelwa. Lokhu kuzokhulisa abasebenzi amathuba okuthi ukuzalwa komntwana okunempilo.