"Mesakol": yokusetshenziswa, nozakwabo yangempela

izilonda emathunjini futhi isifo Crohn kuyagcinwa iziguli kuyinto ngempela ezingavamile. Kodwa, naphezu kwalokhu, kukhona izidakamizwa eminingi okuhloswe zokwelapha lezi zifo. Omunye wabo "Mesakol". Yokusetshenziswa, ifomu, impendulo, kanye nezindleko izimali izokwethulwa ngezansi.

Ukwakheka, ifomu ukukhululwa, emabhokisini kanye nencazelo

Izidakamizwa "Mesakol", ukubuyekezwa okuyizinto umlingiswa edidayo kakhulu, iya ku ukudayiswa njengoba amaphilisi abomvu ansundu. Ziyakwazi enteric-camera futhi ube nohlobo isiyingi futhi we-lenticular wangakwesokunxele.

Ingqikithi oyinhloko ithuluzi kuphuma mesalazine (5-ASA). Ngaphezu ke zomuthi zihlanganisa izingxenye ezengeziwe ezifana corn isitashi, i-calcium ne-phosphate dihydrate, talc sebehlanjululwe microcrystalline cellulose, titanium oxide, hypromellose 2208, Silica Colloid, povidone K90, sodium carboxymethyl isitashi, le copolymer acid methacrylic futhi methyl methacrylate, obomvu yensimbi oxide, macrogol 6000 futhi dibutyl phthalate.

Tablets "Mesakol" enziwa aluminium emapheshana kanye amakhadibhodi amaphakethe ngokulandelana.

kwemithi

Bewazi yini ukuthi umuthi "Mesakol"? Yokusetshenziswa ibonisa ukuthi lokhu ejenti eqeda ukuvuvukala, umphumela lapho itholakala emathunjini. Lokhu impahla nomuthi ngenxa yekhono layo ukuze zivimbele synthesis leukotrienes futhi prostaglandins, futhi neutrophil lipoxygenase.

Kufanele futhi wazi ukuthi izidakamizwa kubhekwe siyehla ukufuduka, phagocytosis futhi degranulation ka neutrophil, kanye immunoglobulin uketshezi ngu-lymphocyte.

Yini nezinye izakhiwo likhona nekhambi "Mesakol", intengo oboniswe ngezansi? Mesalazine Umsebenzi elwa namagciwane ngokumelene ezinye cocci futhi Escherichia coli (ku ikholoni).

Pharmacokinetics

Yiziphi esingokwemvelo kinetic imingcele amaphilisi "Mesakol"? Yokusetshenziswa ithi ngemva kokuphathwa mesalazine ukhululeka igobolondo emva kwemizuzu cishe 115-165, futhi emva kwemizuzu 170-230 amaphilisi chaza.

Ngenxa yokucabangela izidakamizwa ifilimu camera ku 60-80% ikhishwe emathunjini ezinkulu, futhi 15-30% - emathunjini amancane. Kulokhu ketshezi asebenzayo ifinyelela kwegazi kuphela isamba ngo-10% umthamo. Mesalazine lokuhlushwa plasma sincane kakhulu.

Ukuxhumana isithako esisebenzayo plasma amaprotheni kuyinto 43%. Kubhekwe umuthi futhi metabolites yayo ku ubisi lwebele.

Umzimba mesalazine wenziwa emathunjini futhi isibindi. Lokhu kukhipha N-acetyl-5-aminosalicylic acid.

Ingxenye-ukuphila imizuzu 60-120 (kuncike umthamo) ka. Kuboniswa imithi izinso futhi ngokusebenzisa namathumbu.

Izinkomba ukuze bathole imishanguzo engabasiza

Yikuphi ephatha yezifo izidakamizwa "Mesakol"? Uphenyo odokotela babike ukuthi leli thuluzi ngempela ngempumelelo kuzibonakalisa isifo Crohn futhi izilonda emathunjini.

Kufanele kuqashelwe ukuthi nomuthi kubhekwe isetshenziswa hhayi kuphela ukuze kwelashwe izifo okukhulunywe ngawo ngaphambili kodwa futhi nokuvinjelwa exacerbations.

Izimo imithi

Prescribers "Mesakol" hhayi Kunconywa:

• e isilonda peptic wokugaya ukudla;
• izifo igazi;
• esingamahlalakhona ezinzima kwezinso;
• oluhambisana diathesis;
• ebuntwaneni;
• ukungakhuli ezinzima hepatic;
• hypersensitivity kuya izithako zomuthi;
• yokuntuleka zikashukela-6-phosphate dehydrogenase.

Ngokunakekela okukhulu izidakamizwa asetshenziswe okuncane kobukhulu ukwehluleka kwezinso, kanye nokulinganisela omnene esingamahlalakhona hepatic.

Tablets "Mesakol": yokusetshenziswa

Kulaba izimali ezithathwe ngomlomo ngemva nje ukudla.

Phakathi exacerbation yesifo iqondiswa i inani 400-800 mg (ngamanye amazwi, 1-2 amaphilisi) kathathu ngosuku. Yokwelapha yenziwa amasonto 9-12.

Ngokuba nokuvimbela exacerbations kokusetshenziswa kwezidakamizwa ngu-400 mg kathathu ngosuku. Izibhebhe ngokuvamile ngesimo, ukuphuza amanzi avamile.

Indlela izingane izidakamizwa "Mesakol"? Amakhandlela Bheka, microclysters kanye nokumisa - kuleli fomu kuboniswa izidakamizwa izingane.

ukusabela ezingezinhle

Ngeshwa, ukuphuza umuthi kubhekwa kaningi kubangela engemihle. Lezi zihlanganisa lokhu okulandelayo:

• pericarditis, tachycardia, inhliziyo conduction iziyaluyalu, umfutho ophakeme wegazi, ubuhlungu besifuba, hypotension, palpitations, iphika;
• isicanucanu, kwehle esesuthi, ukuhlanza, ukwanda transaminases isibindi, isilungulela, stomatitis, uhudo, isifo sokusha kwesibindi, ubuhlungu besisu, pancreatitis, nomlomo owomile;
• oliguria, proteinuria, crystalluria, hematuria, syndrome nephrotic, anuria;
• isiyezi, ubuhlungu bekhanda, ukuhhema, tinnitus, ukuqwasha, polyneuropathy, Ukudlikizela, liqhaqhazela, ukucindezeleka;
• eosinophilia, thrombocytopenia, anemiya (haemolytic, aplastic, noma megaloblastic), agranulocytosis, ukuntuleka kwegazi emzimbeni, hypoprothrombinemia;
• oligospermia, ubuthakathaka;
• ubuthakathaka, photosensitivity, mumps, ukunciphisa ukukhiqizwa koketshezi izinyembezi, lupus-like syndrome, Alopecia;
• ukuqubuka, dermatitis, pruritus, bronchospasm, erythema.

Izimpawu ukweqisa izidakamizwa

Izimpawu ukweqisa izidakamizwa izindlela kubhekwe aphume ashone izimo ezifana isicanucanu, gastralgia, ukuhlanza, ukozela nobuthakathaka. Ukuze akuqede ezinqunyiwe lavage esiswini laxatives nokwelulekwa lingaze.

Ukuhambelana neminye imikhiqizo

Izidakamizwa "Mesakol" kunciphisa umphumela "spironolactone" "Furosemide", "rifampicin" futhi sulfonamides. Iphinde ithuthukisa imiphumela hypoglycemic ka amagama ahlobene sulfonylurea, lo ubuthi methotrexate futhi corticosteroids ulzerogennosti.

Kumele kuqashelwe futhi ukuthi izidakamizwa siyehla ukumuncwa cyanocobalamin futhi kwandisa umphumela ejenti uricosuric (ie, uketshezi blocker ijabulise) futhi sithuthukisa umphumela anticoagulants.

izincomo ezithile

• Uhudo ezenzeka phakathi ukwelashwa "Mesakolom" alisho ngaso sonke isikhathi umusa ohlangothini umphumela umuthi. isimo esinjalo kungaba izimpawu zezifo ecashile.
• Ngesikhathi yokwamukela, ithuluzi kumele njalo kwenziwe ukuhlolwa kwegazi kanye nomchamo ezivamile.
• Uma umthamo ukuthi awukho, le loku lokulandzelako kufanele kucikelelwe nganoma isiphi esinye isikhathi.
• Phakathi ukwelashwa nale imithi lesiguli umchamo izinyembezi uketshezi kungenzeka amaKhaladi umbala ophuzi.

Izidakamizwa "Mesakol": nozakwabo kanye nezindleko

Buyisela imithi wathi kungaba ngokusebenzisa izinto ezinjengenkolo "salazopiridazina", "5-ASA", "Tidokol" "Asacol", "Samezil", "salofalk", "Mesalazine", "Salozinal", "pentasil".

Kungakanani kukhona "Mesakol" ithebhulethi? Intengo yaleli izidakamizwa ruble 600-680 (amaphilisi 50).

Izibuyekezo umthengi

Iziguli ukushiya "Mesakol" ukulungiselela Izibuyekezo okuxubile kakhulu. Ezinye zazo libike ukuthi izidakamizwa ngempumelelo ephatha isifo emathunjini. Abanye bathi lezi amaphilisi kukhona alunamsebenzi. Ngakho, singaphetha kahle ngokuthi "Mesakol" kunemiphumela ehlukile iziguli ezahlukene.

I ethile eyinhloko lokhu imithi inombolo enkulu contraindications ukusabela ezingezinhle.