"Farmadipin" (amathonsi) kulokho?

Okwamanje, kunezinhlobo amakhambi eziningi ezahlukene ophakeme wegazi kanye stenokardicheskie ukuhlaselwa. Omunye wabo futhi ezifana "Farmadipin" (amathonsi) imithi. Lisho ukuthini leli izidakamizwa, kuxoxwa eminye ngokuningiliziwe.

isakhiwo

Isithako asebenzayo kulokhu nifedipine (nifedipine). 1 ml le solution, kuba ethile. Okungukuthi, ngo-100%, esekelwe ezomile-uhlobo izidakamizwa - 20 mg. It uphendulela amathathu amathonsi.

"Farmadipin" (amaconsi), isiqondiso lapho isicelo kuzoxoxwa engezansi, lesi sakhiwo khona izinto asizayo ezifana polyethylene glycol 400 futhi 96% ethanol.

izakhiwo kwemithi

Lesi sidakamizwa has a pharmacodynamics eyinqaba. Njengoba sekushiwo ngenhla, "Farmadipin" (amathonsi) iqukethe ikhemikhali nifedipine enikeza antihypertensive anti-anginal senzo. It ikhuthaza ekuvimbeni ukungena calcium ion ku cardiomyocytes futhi abushelelezi imisipha amaseli imithambo ezithile neuropathy yenhliziyo ngokusebenzisa voltage-uhlobo iziteshi kancane ehlukene cell ulwelwesi. Le mpahla ebalulekile. Nifedipine futhi inikeza ukuphumula semithambo imisipha bushelelezi, kukhuphuke neuropathy nemithambo yegazi yenhliziyo, nokuqedwa zibe. Lokhu kunciphisa umfutho wegazi, letindzala semithambo ukumelana, afterload zenhliziyo esivimba amanzi nomoya-mpilo funa. Futhi, uma nithatha le izidakamizwa uyaqhubeka ukubonisa izimpawu ezithile. Okungukuthi, kukhona ukwehla okuncane contractility esivimba amanzi futhi inhliziyo umsebenzi, kanye encishisiwe kancane platelet wokuhlanganisa.

Pharmacokinetics

Kule ndaba, "Farmadipin" (amathonsi), yokusetshenziswa okuyinto kubhekwa kulo mbiko, has izici zayo siqu. Lapho i reception yangaphakathi ayenakho ipheshana yesisu ugxile kahle. bioavailability yayo imayelana 40-60 amaphesenti. A ikakhulukazi okusheshayo ukuthuthukiswa nomphumela (ngemva 5-10 imiz) ebonwe ukuqaliswa ekuphathweni sublingual. Kubalulekile ukwazi. Ngokuvamile, umphumela omkhulu kunayo yonke bubonakala imizuzu 30-40. Ukuqala kokusetshenziswa kokungenisa akuyona ikakhulukazi ezithinta izinga ukumuncwa kwe-ejenti. Ukubonakaliswa umphumela hemodynamic uyoqhubeka amahora 4-6. Ngakho-90 amaphesenti nifedipine nakanjani plasma amaprotheni. It akheka ukulungiselela ezifana "Farmadipin" (iconsi) esibindini. Ukuba khona imvume ingqikithi nifedipine ivela 0.4 kuya 0.6 l / kg / ihora. It is lusobala kukho emzimbeni ikakhulu njengoba metabolites uhlobo esingasebenzi. Inkathi isigamu-ukuphila zingahluka kusuka amahora 2 kuya ku-4. Kwasebekhulile kanye neziguli kanye kwesibindi, umzimba nifedipine kubambezela kakhulu. Ngenxa yalokho, banesikhathi isigamu-nokuphila izindlela inkomba zingandiswa cishe 2-emhlanjini. Kulokhu-ke kuyadingeka ukunciphisa umthamo futhi sandise isikhawu phakathi nedili ka ekwakhiweni wathi. Nifedipinv umzimba akuyona cumulated. Futhi kuyo esincane ungakwazi ukungena gazi ebuchosheni futhi umgoqo esinomhlapho. Kulokhu, it is excreted e ngobisi lwebele.

izinkomba

Esimisiwe 'Farmadipin "(iconsi) kulezi zimo ezilandelayo:

• Esimeni nomfutho wegazi ophezulu kubalulekile futhi lingaze.
• Ukuze ukwelashwa kanye nokuvimbela stenokardicheskie ukuhlaselwa.
• zenhliziyo Lapho hypertrophic.
• Lapho isifo Raynaud sika.

isicelo

Thatha "Farmadipin" (amathonsi) sublingually. Lapho ukwanda kokutheleleka kudlange kakhulu umfutho wegazi (isib 180 / 100-190 / 110 mm HG. V.), A umthamo owodwa kokuqala kwezidakamizwa omdala ngokuvamile cishe 3-5 amathonsi (2-3,35 mg). Iziguli ukuguga bunikezwe izilinganiso eziqondile. Okungukuthi - hhayi ningi than 3 amathonsi (mayelana 2 mg). Futhi, inani elithile ungakwazi iconsa ku obuncane isinkwa esomile noma ushukela. nesineke sakhe kufanele ubambe eside ngangokunokwenzeka emlonyeni. Nge enganele Isikali okuholela zomuthi luyanda kancane kancane kuze kube yilapho ngempumelelo emitholampilo. Kulokhu, konke kuncike ekutheni umuntu ngamunye. Ngesikhathi ukubonakaliswa alandelayo akhuphule umfutho wegazi kumele guided ngokuqondile umthamo isethi. Futhi, kukhona omunye umbandela ethize. It itholakala lokuthi ukuthi uma ngizwa ingcindezi igazi rose 190 / 100-220 / 110 mm HG. v., bese ngithatha amathonsi izidakamizwa kungenziwa kancane kancane ukuba 10-15 (6,7-10 mg). Kufanele ikhumbule izinguquko kwengcindezi nesineke inikezwe. Kubalulekile ukwazi.

Kudingeka nokuba acabangele khona ukuzwela anda ezinye iziguli kule izidakamizwa ngokuthi "Farmadipin" (amathonsi), okuyinto Izibuyekezo akhayo. Ezimweni ezinjalo, umthamo kuyakhethwa ngamunye. Thoma ku-3 amathonsi, bese kancane kancane ephakanyiswe 2-3 (1,34-2 mg) kuze kube ngomzuzu lapho oyifunayo umphumela zokwelapha ngendlela abayifunayo.

Kufanele kukhunjulwe ukuthi okweqa umthamo kokuqala zomuthi kungabangela ukwehla abukhali wegazi!

isicinganani

Ngo isicelo sale ukulungiselela ngokuthi "Farmadipin" (Iconsi ingcindezi), kungase kube nezimpawu of isicanucanu, tachycardia, hypotension, "tide" wegazi ebusweni. Kwezinye izimo, bangase baxabane nomzimba ngesimo umlenze edema, ukuqubuka kwesikhumba. Bangase abonise izimpawu lobuthakathaka, isiyezi, ubuhlungu bekhanda.

Izimo

Yokwamukela umuthi onjalo, njengoba "Farmadipin" (iconsi) Akuvunyelwe ukuthwala khona ukuzwela lakhuphuka lafika ku-izingxenye zalo, ukushaqeka cardiogenic, yomthambo i-aorta ezinzima futhi stenosis mitral, hypotension, tachycardia, kanye phakathi nokukhulelwa kanye lactation.

ukweqisa izidakamizwa

Kulokhu, ezinye izimpawu ezingezinhle kungenzeka. Okungukuthi ukweqisa izidakamizwa izidakamizwa ezifana "Farmadipin" (amathonsi), kungaba kuhambisane nesenzakalo ephethwe yisifo senhliziyo, ukushaqeka, lactic umzimba kanye nokugoqana, iconsi elibukhali blood pressure. Lapho ukubonakaliswa lezi zimpawu kuyadingeka ukuze iphendukele izinyathelo ezithile ophuthumayo usizo. Zakhiwa e lavage esiswini, carbon isebenze, i-calcium chloride kanye sympathomimetics isingeniso, ukwelashwa lingaze.

ukusetshenziswa Izici

"Farmadipin" (Iconsi ingcindezi) noma esikhundleni salo ozofakwa kuphela ngokucophelela ukuqashwa kokwelashwa ezigulini esezikhulile futhi iziguli:

- angina engazinzile.

- ukuhluleka kwenhliziyo okukhulu.

- zenhliziyo hypertrophic.

- olunamandla stenosis yomthambo i-aorta.

- ezinzima nomfutho wegazi ophezulu yamaphaphu.

- unhlangothi oyingozi.

- Diabetes mellitus.

- umsebenzi kwezinso nesibindi.

Umthamo neminye imithi esetshenziswa nifedipine kufanele isethwe ngamunye. glycosides senhliziyo futhi angasetshenziswa ngesikhathi yokwamukela imithi efana "Farmadipin" (amathonsi), analogs okuyinto aboniswa ngezansi kulesahluko.

Lapho ethola isicelo ngesikhathi esisodwa nifedipine nge emthanjeni magnesium sulphate abesifazane abakhulelwe kudingeka uvivinye umzimba zokuqapha ngokucophelela blood pressure. Lokhu kumele kwenziwe ngoba kukhona kungenzeka ukwehlisa umfutho wegazi ezingalimaza kumama nele-fetus.

Iziguli kahle ukusebenza hepatic, futhi zidinga zokuqapha ngokucophelela. Ezimweni ezimbi kakhulu, umthamo kumele kungancipha.

tsitohromichnuyu Nifedipine akheka nge uhlelo P450 3A4. Ngenxa yalokho, izidakamizwa ukuthi zivimbela noma ukubanga ecacisiwe endaweni enzyme kungaguqula umphumela "ukuhamba kokuqala" noma imvume ketshezi. Uma ukusetshenziswa concomitant ka nifedipine nezidakamizwa yalolu hlobo kufanele ilawulwe blood pressure. Uma kudingeka, akufanele asebenzise nokuncipha umthamo we izidakamizwa eziyingozi, njengezinto "Farmadipin" (amathonsi).

Ucwaningo ehlukile ngaphandle kwesibeletho ziye zembula izwe ubuhlobo phakathi ukusetshenziswa calcium abamelene kulokhu nifedipine kanye kwamakhemikhali ephambene spermatozoa izinguquko ezithinta Ukuwohloka ikhono omncane ukuba lelisu kokukhulelwa.

Ukuthatha "Farmadipin" (amathonsi), kufanele ugweme imisebenzi uhlobo ezinobungozi, ezidinga ukunakekelwa okukhulu. Okungukuthi, uma akudingekile ukushayela izimoto futhi sisebenze letinye tindlela, nokunye.

ukuxhumana

"Farmadipin" (droplet) has a action hypotensive. Lesi sici sithuthukisa izidakamizwa kusukela isigaba blocker. Okungukuthi, "Farmadipin" (iconsi) kwandisa β-adrenergic imiphumela, isisu, ama-nitrate nama nezinye antihypertensive ejenti, amalungiselelo kanye iziphuzo equkethe utshwala, tricyclic antidepressant. Kwezinye izimo, nifedipine kunciphisa lokuhlushwa quinidine e-plasma. Kodwa ukwesulwa yakhe kakhulu ukhula. Ngakho, usebenzisa ukwelashwa Kunconywa ukuqapha amazinga quinidine lokuhlushwa oketshezini olungenambala lwegazi.

"Diltiazem" kunciphisa imvume izidakamizwa ngokuthi "Farmadipin" (amaconsi). "Fentanyl" kakhulu sithuthukisa ukubonakaliswa umphumela hypotensive. Ngenxa yalokho, ngaphambi kokwenziwa zomuthi (ngaphansi kwamahora 36.) Kufanele umise reception "Farmadipina". ukusetshenziswa ahlangene β-blocker nge nifedipine kungaholela hypotension. "Farmadipin" (lehla) kuthuthukisa lokuhlushwa theophylline, carbamazepine futhi digoxin egazini. "Rifampicin" kuholela buthakathaka umphumela oqabulayo nifedipine, ngaleyo ndlela usheshisa ukuziphatha umzimba walo. "Cimetidine" sithuthukisa lokuhlushwa "Farmadipina" yi-plasma yegazi.

Imigomo nemibandela isitoreji

Kulokhu, kukhona izimfuneko ezithile. Isitolo "Farmadipin" (iconsi) kumele ngaso ekamelweni lokushisa endaweni eyomile. Umuthi kumele bavikelwe ukukhanya kude nezingane. Isitoreji yalesi izidakamizwa yakhelwe kuze 1 unyaka nezinyanga 6. Uma wavula umfuma - kwezinsuku ezingu-28.

iholide

"Farmadipin" (lehla) kungenziwa igcwaliseke kuphela kadokotela.

nokupakisha

Ngo izitsha eziyisikhombisa 25 ml noma 5 ml. Batjala iphakethe.

"Farmadipin" (amathonsi) analogue eRussia

Kukhona esikhundleni eziningi ngenxa yezidakamizwa. Khona-ke abakhululiwe eziyinhloko:

- "cordipin".

- "Nifedipine".

- "Adalat".

- "Kordafleks".

- "Corinfar Uno".

- "Kordafleks RD".

- "fenigidin".

- "Osmo-Adalat".

- "kuthiye cordipin."

- "cordipin XL".

isiphetho

Manje ngoba sewuyazi ukuthi lokho ezifana "Farmadipin" (iconsi) umuthi, okuyindawo kuyasiza futhi yini izindawo. Kunoma ikuphi, ngaphambi kokuthatha lesi izidakamizwa kumele uxhumane kudorhodere.